Incidental Cerebral Microbleeds and Cerebral Blood Flow in Elderly Individuals

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Incidental Cerebral Microbleeds and Cerebral Blood Flow in Elderly Individuals.

IMPORTANCE Cerebral microbleeds (CMBs) are collections of blood breakdown products that are a common incidental finding in magnetic resonance imaging of elderly individuals. Cerebral microbleeds are associated with cognitive deficits, but the mechanism is unclear. Studies show that individuals with CMBs related to symptomatic cerebral amyloid angiopathy have abnormal vascular reactivity and cer...

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Analysis of cerebral lobar microbleeds and a decreased cerebral blood flow in a memory clinic setting.

OBJECTIVE Cerebral microbleeds (MBs) have been previously associated with cognitive dysfunction, including Alzheimer's disease. In the present study, we aimed to clarify the relationship between cerebral lobar MBs and the regional cerebral blood flow (CBF). METHODS We investigated the data obtained from 122 patients in our memory clinic who were examined by both MRI and (99m)Tc-ethyl cysteina...

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APOE genotype and cerebral blood flow in healthy young individuals.

To the Editor: Several epidemiologic studies have found an association between the presence of an apolipoprotein E (APOE) 4 allele and increased risk for Alzheimer disease (AD). Although 2 brain imaging studies of middle-aged and elderly individuals have found that the 4 allele is associated with an ADlike pattern on positron emission tomogrophy (PET) brain scans, we are not aware of any study ...

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Cerebral microbleeds and neuropsychiatric symptoms in an elderly Asian cohort.

OBJECTIVES Neuropsychiatric symptoms (NPS) are commonly found in patients with cerebral small vessel disease such as white matter hyperintensities and lacunar infarcts. However, the association between cerebral microbleeds (CMBs) and NPS has not been examined. Hence the present study sought to investigate the relation between CMBs and NPS in an elderly population. METHODS This is a cross-sect...

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ژورنال

عنوان ژورنال: JAMA Neurology

سال: 2015

ISSN: 2168-6149

DOI: 10.1001/jamaneurol.2015.1359